NEURELIS WINS MULTIPLE AWARDS AS A BEST PLACE TO WORK IN SOUTHERN CALIFORNIA
Company recognized for culture that fosters a highly engaged and passionate team dedicated to improving lives through innovation.
San Diego, CA — October 3, 2023 — Neurelis, Inc. is pleased to announce it has been named one of the Best Places to Work in SoCal 2023 by Best Companies Group (BCG), a BridgeTower Media Company, for the second consecutive year. The Company has also been named to the 2023 list of Best Places to Work in San Diego by the San Diego Business Journal. These award designations were made based on employee feedback and reflect the talented team of dedicated professionals at Neurelis.
"The rapid growth of Neurelis over the last five years, from a handful to more than 175 employees, has been a significant undertaking as we look to serve the epilepsy community and those with other rare neurological conditions," said Co-Founder and CEO of Neurelis, Craig Chambliss. "We have been so fortunate to bring together a team with a collective and sincere passion for bringing life-changing treatments to the people who need them. We will remain steadfast in our commitment to build upon the values that have earned us this honor as we continue this journey."
Through the work of dedicated employees, Neurelis has educated the epilepsy community about the significance of having a seizure action plan and VALTOCO® (diazepam nasal spray) CIV, an FDA-approved product for the short-term treatment of seizure clusters in adult and pediatric patients 6 years of age and older. As a team, Neurelis is fully committed to partner with professional and patient advocacy organizations to significantly advance the care of people suffering from neurological conditions.
"Many of our employees have a personal connection to epilepsy, but everyone at Neurelis feels passionately committed to our mission of helping patients lead fuller lives; as a company we strive to create a work environment that is inspiring, productive, and fulfilling to our employees," said Julia Chernova, Vice-President, Human Resources.
Neurelis, Inc., is a neuroscience company focused on the development and commercialization of therapeutics for the treatment of epilepsy and orphan neurologic disorders characterized by high unmet medical needs. In 2020, the FDA approved Neurelis' VALTOCO® (diazepam nasal spray) as an acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from an individual's usual seizure pattern in adult and pediatric patients 6 years of age and older. VALTOCO is a proprietary formulation of diazepam incorporating the science of INTRAVAIL®. Intravail's transmucosal absorption enhancement technology enables the noninvasive delivery of a broad range of protein, peptide and small-molecule drugs. In its approval of VALTOCO, the U.S. Food and Drug Administration also granted Neurelis Orphan Drug Exclusivity and recognized VALTOCO's intranasal route of administration as a clinically superior contribution to patient care of the previously approved standard-of-care treatment (a rectal gel formulation of diazepam). For more information on VALTOCO, please visit www.valtoco.com. In addition, Neurelis is developing NRL-1049 (previously known as BA-1049), an investigational, Phase I stage small molecule in Rho kinase (ROCK) inhibitor, for the treatment of cerebral cavernous malformations (CCMS), a rare disorder of the central nervous system (CNS). For more information on Neurelis. please visit www.neurelis.com. For the latest scientific information on VALTOCO, please visit http://www.neurelismedicalaffairs.com.
Important Safety Information about VALTOCO
VALTOCO® (diazepam nasal spray) is indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 6 years of age and older.
Contraindications: VALTOCO is contraindicated in patients with:
- Hypersensitivity to diazepam
- Acute narrow-angle glaucoma
Central Nervous System (CNS) Depression
Benzodiazepines, including VALTOCO, may produce CNS depression. Caution patients against engaging in hazardous activities requiring mental alertness, such as operating machinery, driving a motor vehicle, or riding a bicycle, until the effects of the drug, such as drowsiness, have subsided, and as their medical condition permits.
The potential for a synergistic CNS-depressant effect when VALTOCO is used with alcohol or other CNS depressants must be considered, and appropriate recommendations made to the patient and/or care partner.
Suicidal Behavior and Ideation
Antiepileptic drugs (AEDs), including VALTOCO, increase the risk of suicidal ideation and behavior. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or unusual changes in mood or behavior.
Benzodiazepines, including VALTOCO, can increase intraocular pressure in patients with glaucoma. VALTOCO may be used in patients with open-angle glaucoma only if they are receiving appropriate therapy. VALTOCO is contraindicated in patients with narrow-angle glaucoma.
Neonatal Sedation and Withdrawal Syndrome
Use of VALTOCO late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in the neonate. Monitor neonates exposed to VALTOCO during pregnancy or labor for signs of sedation and monitor neonates exposed to VALTOCO during pregnancy for signs of withdrawal; manage these neonates accordingly.
Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preservative
VALTOCO is not approved for use in neonates or infants. Serious and fatal adverse reactions, including “gasping syndrome,” can occur in neonates and low-birth-weight infants treated with benzyl alcohol–preserved drugs, including VALTOCO. The “gasping syndrome” is characterized by central nervous system depression, metabolic acidosis, and gasping respirations. The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known.
The most common adverse reactions (at least 4%) were somnolence, headache, and nasal discomfort.
Diazepam, the active ingredient in VALTOCO, is a Schedule IV controlled substance.
To report SUSPECTED ADVERSE REACTIONS, contact Neurelis, Inc. at 1-866-696-3873 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).
Please read full Prescribing Information, including Boxed Warning.
Brittany Bradrick, Chief Operating Officer and Chief Financial Officer, +1 858 251 2135
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